The bone marrow side of axial spondyloarthritis

D Mauro, S Gandolfo, E Tirri, G Schett… - Nature Reviews …, 2023 - nature.com
Spondyloarthritis (SpA) is characterized by the infiltration of innate and adaptive immune
cells into entheses and bone marrow. Molecular, cellular and imaging evidence …

Enthesis repair–State of play

E Pugliese, A Rossoni, DI Zeugolis - Biomaterials Advances, 2024 - Elsevier
The fibrocartilaginous enthesis is a highly specialised tissue interface that ensures a smooth
mechanical transfer between tendon or ligament and bone through a fibrocartilage area …

Effects of mineralization on the hierarchical organization of collagen—a synchrotron X-ray scattering and polarized second harmonic generation study

K Zheng, J Zhong, J Hu, E Nebbiolo… - Interface …, 2024 - royalsocietypublishing.org
The process of mineralization fundamentally alters collagenous tissue biomechanics. While
the structure and organization of mineral particles have been widely studied, the impact of …

Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice

E Ganji, SN Lamia, M Stepanovich, N Whyte… - Science …, 2023 - science.org
Skeletal shape depends on the transmission of contractile muscle forces from tendon to
bone across the enthesis. Loss of muscle loading impairs enthesis development, yet little is …

[HTML][HTML] Hypertrophic chondrocytes at the junction of musculoskeletal structures

N Chen, RWH Wu, Y Lam, WCW Chan, D Chan - Bone Reports, 2023 - Elsevier
Hypertrophic chondrocytes are found at unique locations at the junction of skeletal tissues,
cartilage growth plate, articular cartilage, enthesis and intervertebral discs. Their role in the …

Decoding the mechanical characteristics of the human anterior cruciate ligament entheses through graduated mineralization interfaces

J Fang, X Wang, H Lai, W Li, X Yao, Z Pan… - Nature …, 2024 - nature.com
The anterior cruciate ligament is anchored to the femur and tibia via specialized interfaces
known as entheses. These play a critical role in ligament homeostasis and joint stability by …

Upregulation of Runt related transcription factor 1 (RUNX1) contributes to tendon–bone healing after anterior cruciate ligament reconstruction using bone …

K Kang, Q Geng, L Cui, L Wu, L Zhang, T Li… - Journal of orthopaedic …, 2022 - Springer
Background Anterior cruciate ligament (ACL) injury could lead to functional impairment
along with disabilities. ACL reconstruction often fails owing to the regeneration failure of …

Therapeutic Potential of Exosomes in Tendon and Tendon–Bone Healing: A Systematic Review of Preclinical Studies

M Zou, J Wang, Z Shao - Journal of Functional Biomaterials, 2023 - mdpi.com
Exosomes have been proven to play a positive role in tendon and tendon–bone healing.
Here, we systematically review the literature to evaluate the efficacy of exosomes in tendon …

[HTML][HTML] Impaired 1, 25-dihydroxyvitamin D3 action underlies enthesopathy development in the Hyp mouse model of X-linked hypophosphatemia

R Rana, JT Baker, M Sorsby, S Jagga, S Venkat… - JCI insight, 2023 - ncbi.nlm.nih.gov
X-linked hypophosphatemia (XLH) is characterized by high serum fibroblast growth factor 23
(FGF23) levels, resulting in impaired 1, 25-dihydroxyvitamin D 3 (1, 25D) production. Adults …

[HTML][HTML] Recent developments in Achilles tendon risk-analyzing rupture factors for enhanced injury prevention and clinical guidance: Current implications of …

MV Sankova, NM Beeraka, MV Oganesyan… - Journal of Orthopaedic …, 2024 - Elsevier
Background In recent years, many countries have actively implemented programs and
strategies to promote physical education and sports. Despite these efforts, the increase in …