Hydrogen sulfide (H2S) is an emerging neuromodulator that is considered to be a
gasotransmitter similar to nitrogen oxide (NO) and carbon monoxide (CO). H2S exerts …

Although Schwann cell myelin breakdown is the universal outcome of a remarkably wide
range of conditions that cause disease or injury to peripheral nerves, the cellular and …

Myelinating Schwann cells undergo irreversible demyelination in many demyelinating
neuropathies that show complete demyelination of the internode. Dedifferentiation …

Schwann cells (SCs) in animals exist in different developmental stages or wound repair
phases, distinguished mainly by the expression of SC-specific markers. No study has yet …

Impairment of peripheral neurons by anti-cancer agents, including taxanes and platinum
derivatives, has been considered to be a major cause of chemotherapy-induced peripheral …

Oxidative stress contributes to the progression of neurodegenerative diseases of the central
and peripheral nervous systems, including Alzheimer's disease, Parkinson's disease, stroke …

In the PNS, myelination occurs postnatally when Schwann cells (SCs) contact axons. Axonal
factors, such as Neuregulin-1 Type III, trigger promyelinating signals that upregulate myelin …

Schwann cells (SCs) are the principal glia of the peripheral nervous system. The end point
of SC development is the formation of myelinating and nonmyelinating cells which ensheath …

Schwann cells (SCs), which form the peripheral myelin sheath, have the unique ability to
dedifferentiate and to destroy the myelin sheath under various demyelination conditions …

Abstract Background: Schwann cells (SCs) secrete neurotrophic factors and provide
structural support and guidance during axonal regeneration. However, nearby nerves may …