The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …

Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Native mass spectrometry (nMS) is evolving into a workhorse for structural biology. The
plethora of online and offline preparation, separation, and purification methods as well as …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Mass spectrometry is well-established as one of the primary methods used to characterize
peptides and proteins. New advances in instrumentation and innovative analytical workflows …

Covalent labeling (CL) in combination with mass spectrometry can be used as an analytical
tool to study and determine structural properties of protein-protein complexes. However …

Progress in structural biology research has led to a high demand for powerful and yet
complementary analytical tools for structural characterization of proteins and protein …

Knowledge of protein structure is paramount to the understanding of biological function,
developing new therapeutics, and making detailed mechanistic hypotheses. Therefore …

Native mass spectrometry has emerged as an important tool for gas-phase structural
biology. However, the conformations that a biomolecular ion adopts in the gas phase can …

Hydroxyl radical protein footprinting (HRPF) in combination with mass spectrometry reveals
the relative solvent exposure of labeled residues within a protein, thereby providing insight …