Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

Highlights•Early caregiving adversity is associated with poor mental health
outcomes.•Across species, adversity accelerates the developmental trajectory of emotion …

Although early-life adversity can undermine healthy development, children growing up in
harsh environments may develop intact, or even enhanced, skills for solving problems in …

Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala
are immature during childhood and become adult-like during adolescence. Rodent models …

Major depression and anxiety disorders have high prevalence rates and are frequently
comorbid. The neurobiological bases for these disorders are not fully understood, and …

A review of the human developmental neuroimaging literature that investigates outcomes
following exposure to psychosocial adversity is presented with a focus on two subcortical …

Early experiences critically shape the structure and function of the brain. Perturbations in
typical/species-expected early experiences are known to have profound neural effects …

Background Perinatal maternal depression is a serious health concern with potential lasting
negative consequences for children. Prenatal depression is associated with altered brain …

Maternal separation and poor maternal care in animals have been shown to have important
effects on the developing hippocampus and amygdala. In humans, children exposed to …

Discriminating neural abnormalities into the causes versus consequences of
psychopathology would enhance the translation of neuroimaging findings into clinical …