Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Accurate estimation of the number of ovarian follicles at various stages of development is an
important indicator of the process of folliculogenesis in relation to the endocrine signals and …

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the
toxic activity of many environmental xenobiotics. However, its role in innate immune …

The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that
bound and mediated the toxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) …

BACKGROUND Cigarette smoking is associated with lower fecundity rates, adverse
reproductive outcomes and a higher risk of IVF failures. Over the last few decades …

Animals have evolved inducible enzymatic defenses to facilitate the biotransformation and
elimination of toxic compounds encountered in the environment. The sensory component of …

Organogenesis of the ovary is a highly orchestrated process involving multiple lineage
determination of ovarian surface epithelium, granulosa cells and theca cells. Although the …

The world's population is increasing at an alarming rate and is projected to reach nine billion
by 2050. Despite this, 15% of couples world-wide remain childless because of infertility. Few …

Endocrine-disrupting chemicals (EDCs) are exogenous agents with the ability to interfere
with processes regulated by endogenous hormones. One such process is female …