The use of plant secondary metabolites has gained considerable attention among clinicians
in the prevention and treatment of cancer. A secondary metabolite isolated mainly from the …

Cancer is one of the deadliest non communicable diseases. Numerous anticancer
medications have been developed to target the molecular pathways driving cancer …

Marine bioprospecting, which involves the exploration of genetic and biochemical material
from marine organisms, can be used towards addressing a broad range of public and …

Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis,
and its development involves abnormalities in multiple signaling pathways. Surgery …

Abdominal aortic aneurysm (AAA) is a lethal cardiovascular disease, and there is no proven
drug treatment for this condition. In this study, by using the Connectivity Map (CMap) …

Natural products have long been valuable sources of inspiration for drug discovery.
Unfortunately, the inherent limitations of direct semisynthetic derivatizations have become …

The DNA topoisomerase enzymes are widely distributed throughout all spheres of life and
are necessary for cell function. Numerous antibacterial and cancer chemotherapeutic drugs …

Lung cancer, a leading global cause of mortality, poses a significant public health challenge
primarily linked to tobacco use. While tobacco contributes to over 90% of cases, factors like …

Cancer is the leading cause of death and has remained a big challenge for the scientific
community. Because of the growing concerns, new therapeutic regimens are highly …

Transcription factors have proven difficult to target with small molecules because they lack
pockets necessary for potent binding. Disruption of protein expression can suppress targets …