Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Pyroptosis is a recently described mechanism of programmed cell death mediated by
proteins of the gasdermin family. Widely recognized signaling cascades include the …

Due to the high genetic heterogeneity of hearing loss (HL), current clinical testing includes
sequencing large numbers of genes, which often yields a significant number of novel …

Pyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory
diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a …

Gasdermin E (GSDME), a gene originally involved in hereditary hearing loss, has been
associated with several types of cancer in the last two decades. Recently, GSDME was …

Simple Summary Pyroptosis is a new form of programmed cell death that differs from
apoptosis in terms of its release of inflammatory factors and its characteristic bubble-like …

Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates
programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that …

Hereditary hearing loss is both clinically and genetically very heterogeneous. Despite the
large number of genes that have been associated with the condition, many cases remain …

Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in
the plasma membrane, and cells swell, rupture, and then release their contents, including …

Background DFNA5 (GSDME) belongs to Gasdermin familily that is involved in a variety of
cancers and triggers cell pyroptosis after chemical treatment. However, the relationship in …