Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and
devastating septicemia. Although effective vaccines exist for several serogroups of …

The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

Advances in genomics and innovative strategies such as reverse vaccinology have changed
the concepts and approaches to vaccine candidate selection and design. Genome mining …

Introduction: Neisseria meningitidis serogroup B (MenB) is the most common cause of
bacterial meningitis in many industrialized countries and occurs at any age. The highest …

Neisseria meningitidis is a Gram-negative microorganism that exists exclusively in humans
and can cause devastating invasive disease. Although capsular polysaccharide-based …

Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for
understanding the nature of immune responses and designing improved vaccines …

Neisseria meningitidis (Nm) clonal complex 11 (cc11) lineage is a hypervirulent pathogen
responsible for outbreaks of invasive meningococcal disease, including among men who …

Reverse vaccinology (RV), the first application of genomic technologies in vaccine research,
represented a major revolution in the process of discovering novel vaccines. By determining …

Introduction: The successful development of two broadly protective vaccines targeting
Neisseria meningitidis serogroup B (MenB); 4CMenB and rLP2086, is the most significant …

Bexsero® is a multicomponent vaccine composed of four major proteins of Neisseria
meningitidis: the fHbp, NHBA, NadA and PorA. This vaccine was licensed against invasive …