Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR)
family. Compared to other GPCRs, the specificity of the four PARs is the lack of …

Inflammatory Bowel Diseases (IBD) are chronic inflammatory disorders, where epithelial
defects drive, at least in part, some of the pathology. We reconstituted human intestinal …

Inflammatory diseases have become increasingly prevalent throughout the world.
Coronavirus disease 2019 (COVID‐19), which has recently become pandemic, also exhibits …

Proteolytic homeostasis is important at mucosal surfaces, but its actors and their precise role
in physiology are poorly understood. Here we report that healthy human and mouse colon …

Abstract Background and Aims Thrombin levels in the colon of Crohn's disease patients
have recently been found to be elevated 100-fold compared with healthy controls. Our aim …

Imbalance between proteases and their inhibitors plays a crucial role in the development of
Inflammatory Bowel Diseases (IBD). Increased elastolytic activity is observed in the colon of …

Introduction Certain low-molecular-weight heparins have been reported to reduce tumor
growth and metastasis in tumor cell-inoculated mouse models and cancer patients …

Inflammatory bowel disease (IBD) is a chronic, recurrent inflammatory disease caused by
the destruction of the intestinal mucosal epithelium that affects a growing number of people …

The cytolethal distending toxin (CDT) is produced by several Gram-negative pathogenic
bacteria. In addition to inflammation, experimental evidences are in favor of a protumoral …

The pathogenesis and course of inflammatory bowel diseases are related to both immune
system disorders and dysfunction of colon permeability. Moreover, co-existing diseases in …