Alzheimer's Disease (AD) is a chronic neurodegenerative disease that affects over 5 million
individuals in the United States alone. Currently, there are only two kinds of pharmacological …

Stroke is a medical emergency that is associated with substantial mortality and functional
disability in adults. The most popular class of antidepressants, selective serotonin reuptake …

Memory impairments are frequently reported in patients suffering from brain ischemic
diseases. Oxidative/nitrosative stress, synaptic plasticity, and brain-derived neurotrophic …

The protective role of hydrogen sulfide against cerebral ischemia-reperfusion injury involves
the inhibition of the RhoA-/Rho-associated coiled-coil kinase (ROCK) pathway. However …

Global cerebral ischemia/reperfusion (I/R) induces selective neuronal injury in the
hippocampus, leading to severe impairment in behavior, learning, and memory functions …

Bone marrow stromal stem cells (BMSCs) play a significant role in cell therapy. These cells
quickly die after transplantation to the affected area due to oxidative stress. The natural …

Purpose Cerebral ischemia is the result of decreased or interrupted blood flow to the brain. It
is the third leading cause of death after cardiovascular disease and cancer. Cerebral …

Background Paroxetine (PX) is a widely used antidepressant with side effects such as
weakness, dizziness, and trouble sleeping. In search of novel compounds with better …

Methods: Transient occlusion of common carotid arteries was used to induce
ischemiareperfusion injury in rats. Single or multiple (once daily for 7 days) dose (s) of …

Methods: Animals were randomly divided into control, sham and STZ groups receiving
streptozotocin 2, 3, 4 and 5 mg/kg through intracerebroventriclular (icv) injection. Learning …