Functions of sphingolipids in pathogenesis during host–pathogen interactions

J Wang, YL Chen, YK Li, DK Chen, JF He… - Frontiers in …, 2021 - frontiersin.org
Sphingolipids are a class of membrane lipids that serve as vital structural and signaling
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …

Old and new strategies in therapy and diagnosis against fungal infections

T Vanzolini, M Magnani - Applied Microbiology and Biotechnology, 2024 - Springer
Fungal infections represent a serious global health threat. The new emerging pathogens
and the spread of different forms of resistance are now hardly challenging the tools available …

Farnesol Boosts the Antifungal Effect of Fluconazole and Modulates Resistance in Candida auris through Regulation of the CDR1 and ERG11 Genes

J Dekkerová, L Černáková, S Kendra, E Borghi… - Journal of Fungi, 2022 - mdpi.com
Candida auris is considered a serious fungal pathogen frequently exhibiting a high
resistance to a wide range of antifungals. In this study, a combination of the quorum-sensing …

[HTML][HTML] Untargeted lipidomics reveals the antifungal mechanism of essential oils nanoemulsion against Penicillium digitatum

R Yang, J Miao, Z Zhang, C Wan, L Zou, C Chen… - LWT, 2022 - Elsevier
Abstract Eugenol (EUG), cinnamaldehyde (CA), and carvacrol (CAR) have been used to
prevent fungal invasion due to their potent inhibitory activity. However, nanoemulsion can …

Effect of 1-alkyl-1-methylpiperidinium bromides on lipids of fungal plasma membrane and lung surfactant

K Dopierała, A Syguda, M Wojcieszak… - Chemistry and Physics of …, 2022 - Elsevier
This study aimed to investigate the potential of 1-alkyl-1-methylpiperidinium bromides as
fungicides and evaluate their impact on the human respiratory system when spread in the …

Sphingolipid diversity in Candida auris: unraveling interclade and drug resistance fingerprints

B Ali, M Kumar, P Kumar, A Chauhan… - FEMS Yeast …, 2024 - academic.oup.com
In this study, we explored the sphingolipid (SL) landscape in Candida auris, which plays
pivotal roles in fungal biology and drug susceptibility. The composition of SLs exhibited …

The sphingolipid inhibitor myriocin increases Candida auris susceptibility to amphotericin B

H Stieber, L Junghanns, H Wilhelm, M Batliner… - Mycoses, 2024 - Wiley Online Library
Background The emergence of the pathogenic yeast Candida auris is of global concern due
to its ability to cause hospital outbreaks and develop resistance against all antifungal drug …

[HTML][HTML] A Comprehensive Analysis of the Lipidomic Signatures in Rhizopus delemar

B Ali, A Chauhan, M Kumar, P Kumar, H Carolus… - Journal of Fungi, 2024 - mdpi.com
Certain species of Mucorales have been identified as causative agents of mucormycosis, a
rare yet often lethal fungal infection. Notably, these fungi exhibit intrinsic resistance to …

Diacylglycerol metabolism and homeostasis in fungal physiology

S Mondal, B Pal, R Sankaranarayanan - FEMS Yeast Research, 2024 - academic.oup.com
Diacylglycerol (DAG) is a relatively simple and primitive form of lipid, which does not
possess a phospholipid headgroup. Being a central metabolite of the lipid metabolism …

[HTML][HTML] Characterization and Differentiation of Candida auris on Dixon's Agar Using Raman Spectroscopy

C Petrokilidou, E Pavlou, A Velegraki, A Simou… - Pathogens, 2024 - mdpi.com
Candida auris, an emerging multidrug-resistant fungal pathogen, poses significant
challenges in healthcare settings due to its high misidentification rate and resilience to …