[HTML][HTML] Anti-tuberculosis treatment strategies and drug development: challenges and priorities
VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …
biological uncertainties remain and hamper progress. However, owing to collaborative …
Immune cell interactions in tuberculosis
JAL Flynn, J Chan - Cell, 2022 - cell.com
Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
Mechanisms of drug-induced tolerance in Mycobacterium tuberculosis
SN Goossens, SL Sampson… - Clinical microbiology …, 2020 - Am Soc Microbiol
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …
populations that are temporarily able to survive antibiotic pressure in the absence of drug …
Biology of antimicrobial resistance and approaches to combat it
SM Schrader, J Vaubourgeix, C Nathan - Science translational …, 2020 - science.org
Insufficient development of new antibiotics and the rising resistance of bacteria to those that
we have are putting the world at risk of losing the most widely curative class of medicines …
we have are putting the world at risk of losing the most widely curative class of medicines …
[HTML][HTML] Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis
Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …
largest single contributor to human mortality due to antimicrobial resistance. A few major …
[图书][B] Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance
World Health Organization - 2023 - books.google.com
Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
Tuberculosis treatment failure associated with evolution of antibiotic resilience
The widespread use of antibiotics has placed bacterial pathogens under intense pressure to
evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis …
evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis …
Drug-resistant tuberculosis: a persistent global health concern
Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …
[HTML][HTML] Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges
Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …
Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity
Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH< 5.8) and is thought
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …