Self-assembly is a ubiquitous process in synthetic and biological systems, broadly defined
as the spontaneous organization of multiple subunits (macromolecules, particles, etc.) into …

The advent of nanoscience and nanotechnology and the development of atomic force
microscopy and other single-molecule techniques are leading to a renewed look at viruses …

Viruses play a role in a significant portion of human diseases, as well as those of other
animals, plants, and bacteria. This chapter focuses on the use of theoretical and …

The hepatitis B virus capsid represents a promising therapeutic target. Experiments suggest
the capsid must be flexible to function; however, capsid structure and dynamics have not …

Hepatitis B virus (HBV) is an endemic, chronic virus that leads to 800000 deaths per year.
Central to the HBV lifecycle, the viral core has a protein capsid assembled from many copies …

Capsid maturation with large-scale subunit reorganization occurs in virtually all viruses that
use a motor to package nucleic acid into preformed particles. A variety of ensemble studies …

Coarse-grained (CG) molecular models are now widely used to understand the structure
and functionality of macromolecular self-assembling systems. In the last few years …

The propensity for capsid disassembly and uncoating of human adenovirus is modulated by
interactions with host cell molecules like integrins and alpha defensins. Here, we use atomic …

Featured Application Sizing and measurement of vibrational frequencies of viruses could be
useful for diagnostic purposes, as well as for targeted destruction via resonant excitation of …

Bacterial microcompartments are large, roughly icosahedral shells that assemble around
enzymes and reactants involved in certain metabolic pathways in bacteria. Motivated by …