New antiprotozoals active against Philasterides dicentrarchi, the causative agent of
scuticociliatosis in farmed turbot and Black Sea bass-bream, have been synthesised and …

2.1. 1 Halogenation–coupling 2.1. 2 Metalation–halogenation–coupling 2.1. 3 Metalation–
transmetalation–coupling 2.1. 4 N-Arylation of heteroaromatics 2.1. 5 Examples of rapid …

Nowadays, antimicrobial therapies have become a very challenging issue because of a
large diversity of reasons such as antimicrobial resistance, over consumption and misuse of …

Pyridine‐2 (1H)‐thiones were prepared and reacted with several active halogenated
reagents to afford novel thieno [2, 3‐b] pyridines in excellent yields. Thieno [2, 3‐b] pyridine …

Certain pyridothienopyrimidine derivatives exhibit antiatheroscleorotic, antibacterial,
antiviral, antidepressant, antidiabetic, antihypertensive, anticancer, antihistaminic …

Abstract The reaction between 3‐amino‐2, 3‐dihydro‐7, 9‐dimethyl‐2‐thioxo‐pyrido [3′,
2′: 4, 5] thieno [3, 2‐d]‐pyrimidin‐4 (1H)‐one 4 or its 2‐methylthio derivative 5 with …

A series of pyrido [3′, 2′: 4, 5] thieno [3, 2-d] pyrimidines (PTP) has been synthesized and
tested as phosphodiesterase IV inhibitors (PDE4), a target for the treatment of asthma and …

Abstract New series of pyrido [3′, 2′: 4, 5] thieno [3, 2-d] pyrimidines (7a, b) and thieno [2,
3-b: 4, 5-b′] dipyridine (11a–c) were synthesized from 4-aryl-6-(4-chlorophenyl)-2-thioxo-1 …

Найдены новые эффективные рострегуляторы в ряду пиридо-тиенопиримидина.
Приведены физико-химические характеристики 2-(2-нитрофенил)-7, 9-диметил-и 2-(2 …

The Ca 2+/calmodulin-dependent protein phosphatase calcineurin is a key mediator in
antigen-specific T cell activation. Thus, inhibitors of calcineurin, such as cyclosporin A or …