Clinical review: intensive care unit acquired weakness

G Hermans, G Van den Berghe - Critical care, 2015 - Springer
A substantial number of patients admitted to the ICU because of an acute illness,
complicated surgery, severe trauma, or burn injury will develop a de novo form of muscle …

Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects

FH Kobeissy - 2015 - books.google.com
With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

[HTML][HTML] Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study

R Frithiof, E Rostami, E Kumlien, J Virhammar… - Clinical …, 2021 - Elsevier
Objective The aim was to characterize the electrophysiological features and plasma
biomarkers of critical illness polyneuropathy (CIN) and myopathy (CIM) in coronavirus …

Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation?

B Bircak-Kuchtova, HY Chung, J Wickel, J Ehler… - Critical Care, 2023 - Springer
Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis
patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute …

[HTML][HTML] Fluid biomarkers for monitoring structural changes in polyneuropathies: their use in clinical practice and trials

L Wieske, D Smyth, MP Lunn, F Eftimov, CE Teunissen - Neurotherapeutics, 2021 - Elsevier
Reliable and responsive tools for monitoring disease activity and treatment outcomes in
patients with neuropathies are lacking. With the emergence of ultrasensitive blood …

Neurofilament light increases over time in severe COVID-19 and is associated with delirium

PJ Smeele, L Vermunt, S Blok, JW Duitman… - Brain …, 2022 - academic.oup.com
Neurological monitoring in sedated Intensive Care Unit patients is constrained by the lack of
reliable blood-based biomarkers. Neurofilament light is a cross-disease biomarker for …

Neuro-axonal injury in COVID-19: the role of systemic inflammation and SARS-CoV-2 specific immune response

C Hirzel, D Grandgirard, B Surial… - Therapeutic …, 2022 - journals.sagepub.com
Background: In coronavirus disease-2019 (COVID-19) patients, there is increasing evidence
of neuronal injury by the means of elevated serum neurofilament light chain (sNfL) levels …

A conceptual framework: the early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndrome

DC Files, MA Sanchez, PE Morris - Critical care, 2015 - Springer
Patients with acute respiratory distress syndrome (ARDS) often develop severe
diaphragmatic and limb skeletal muscle dysfunction. Impaired muscle function in ARDS is …

Urinary titin is a novel biomarker for muscle atrophy in nonsurgical critically ill patients: a two-center, prospective observational study

N Nakanishi, R Tsutsumi, K Hara… - Critical Care …, 2020 - journals.lww.com
Objectives: Although skeletal muscle atrophy is common in critically ill patients, biomarkers
associated with muscle atrophy have not been identified reliably. Titin is a spring-like protein …

Intensive care unit-acquired weakness

J Horn, G Hermans - Handbook of Clinical Neurology, 2017 - Elsevier
When critically ill, a severe weakness of the limbs and respiratory muscles often develops
with a prolonged stay in the intensive care unit (ICU), a condition vaguely termed intensive …