Systemic autoimmune diseases (SADs) are a group of connective tissue diseases with
diverse, yet overlapping, symptoms and autoantibody development. The etiology behind …

Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong
genetic component, characterized by hyperactive T and B cells, autoantibody production …

We previously reported a genome-wide association study (GWAS) identifying 14
susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals …

Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the
molecular mechanism that negatively regulates this critical step is poorly understood. Here …

The etiology of SLE is not fully established. SLE is a disease with periods of waning disease
activity and intermittent flares. This fits well in theory to a latent virus infection, which …

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic
component and is characterized by chronic inflammation and the production of anti-nuclear …

Vitiligo is an autoimmune disease with a strong genetic component, characterized by areas
of depigmented skin resulting from loss of epidermal melanocytes. Genetic factors are …

At a time when complex diseases affect globally 280 million people and claim 14 million
lives every year, there is an urgent need to rapidly increase our knowledge into their …

Objective To characterize baseline gene expression and pharmacodynamically induced
changes in whole blood gene expression in 1,760 systemic lupus erythematosus (SLE) …

Vitiligo is a common acquired depigmentation disorder of the skin manifested by the
presence of white macules. The disease occurs at a frequency of approximately 1–4% of the …