The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …

Chemotaxis is a fundamental guidance mechanism of cells and organisms, responsible for
attracting microbes to food, embryonic cells into developing tissues, immune cells to …

Despite a growing wealth of available molecular data, the growth of tumors, invasion of
tumors into healthy tissue, and response of tumors to therapies are still poorly understood …

During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the
sprout to compete for the tip position. We recently identified a key role for the glycolytic …

Angiogenesis plays important roles in development, stress response, wound healing,
tumorigenesis and cancer progression, diabetic retinopathy, and age-related macular …

During vessel sprouting, endothelial “tip” cells migrate at the forefront, while the endothelial
“stalk” cells elongate the sprout; endothelial “phalanx” cells line quiescent vessels. Tip and …

The adequate and efficient functioning of the microcirculation requires not only numerous
vessels providing a large surface area for transport but also a structure that provides short …

Angiogenesis is critical during development, wound repair, and cancer progression. During
angiogenesis, some endothelial cells adopt a tip phenotype to lead the formation of new …