Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
The risks of miRNA therapeutics: in a drug target perspective
S Zhang, Z Cheng, Y Wang, T Han - Drug design, development …, 2021 - Taylor & Francis
RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs,
were approved by the Food and Drug Administration in 2018 and 2019, respectively …
were approved by the Food and Drug Administration in 2018 and 2019, respectively …
Mechanisms of HBV-induced hepatocellular carcinoma
M Levrero, J Zucman-Rossi - Journal of hepatology, 2016 - Elsevier
Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review
K Liu, M Zheng, R Lu, J Du, Q Zhao, Z Li, Y Li… - Cancer Cell …, 2020 - Springer
One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by
an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives …
an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives …
Exosomes derived from miR‐181‐5p‐modified adipose‐derived mesenchymal stem cells prevent liver fibrosis via autophagy activation
Y Qu, Q Zhang, X Cai, F Li, Z Ma… - Journal of cellular and …, 2017 - Wiley Online Library
Proliferating hepatic stellate cells (HSC s) respond to liver damage by secreting collagens
that form fibrous scar tissue, which can lead to cirrhosis if in appropriately regulated …
that form fibrous scar tissue, which can lead to cirrhosis if in appropriately regulated …
Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier
N Tominaga, N Kosaka, M Ono, T Katsuda… - Nature …, 2015 - nature.com
Brain metastasis is an important cause of mortality in breast cancer patients. A key event
during brain metastasis is the migration of cancer cells through blood–brain barrier (BBB) …
during brain metastasis is the migration of cancer cells through blood–brain barrier (BBB) …
The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling
P Han, J Li, B Zhang, J Lv, Y Li, X Gu, Z Yu, Y Jia, X Bai… - Molecular cancer, 2017 - Springer
Background With more than 600,000 mortalities each year, colorectal cancer (CRC) is the
third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving …
third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving …
Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma
A Arzumanyan, HM Reis, MA Feitelson - Nature Reviews Cancer, 2013 - nature.com
Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …
Cancer stem cells in the development of liver cancer
T Yamashita, XW Wang - The Journal of clinical …, 2013 - Am Soc Clin Investig
Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor
markers are useful for isolating a subset of liver cells with stem cell features, known as …
markers are useful for isolating a subset of liver cells with stem cell features, known as …
The evolving concept of liver cancer stem cells
K Nio, T Yamashita, S Kaneko - Molecular cancer, 2017 - Springer
Liver cancer is an often fatal malignant tumor with a high recurrence rate and
chemoresistance. The major malignant phenotypes of cancer, including recurrence …
chemoresistance. The major malignant phenotypes of cancer, including recurrence …