Genetically encoded tools for in vivo G‐protein‐coupled receptor agonist detection at cellular resolution

KE Kroning, W Wang - Clinical and Translational Medicine, 2022 - Wiley Online Library
G‐protein‐coupled receptors (GPCRs) are the most abundant receptor type in the human
body and are responsible for regulating many physiological processes, such as sensation …

Protein-Based Tools for Studying Neuromodulation

W Wang - ACS Chemical Biology, 2024 - ACS Publications
Neuromodulators play crucial roles in regulating neuronal activity and affecting various
aspects of brain functions, including learning, memory, cognitive functions, emotional states …

Adaptable, turn-on maturation (ATOM) fluorescent biosensors for multiplexed detection in cells

H Sekhon, JH Ha, MF Presti, SB Procopio, AR Jarvis… - Nature …, 2023 - nature.com
A grand challenge in biosensor design is to develop a single-molecule, fluorescent protein-
based platform that can be easily adapted to recognize targets of choice. Here, we created a …

Modular peroxidase-based reporters for detecting protease activity and protein interactions with temporal gating

G Zhou, WW Wan, W Wang - Journal of the American Chemical …, 2022 - ACS Publications
Enzymatic reporters have been widely applied to study various biological processes
because they can amplify signal through enzymatic reactions and provide good sensitivity …

Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists

K Kroning, N Gannot, X Li, A Putansu… - Proceedings of the …, 2024 - National Acad Sciences
G protein-coupled receptors (GPCRs) transduce the effects of many neuromodulators
including dopamine, serotonin, epinephrine, acetylcholine, and opioids. The localization of …

A Neural Control Circuit for Cough-Like Defensive Behaviors in Mice

N Gannot - 2024 - deepblue.lib.umich.edu
Breathing is a vital and complex behavior that rapidly responds to the physiological states
and stimuli in the body. Breathing patterns are controlled by the brainstem, which receives …