Neocortical layer 1: an elegant solution to top-down and bottom-up integration

B Schuman, S Dellal, A Prönneke… - Annual review of …, 2021 - annualreviews.org
Many of our daily activities, such as riding a bike to work or reading a book in a noisy cafe,
and highly skilled activities, such as a professional playing a tennis match or a violin …

Connectomic comparison of mouse and human cortex

S Loomba, J Straehle, V Gangadharan, N Heike… - Science, 2022 - science.org
The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

[HTML][HTML] Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity

NL Turner, T Macrina, JA Bae, R Yang, AM Wilson… - Cell, 2022 - cell.com
We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

A dendrite-focused framework for understanding the actions of ketamine and psychedelics

NK Savalia, LX Shao, AC Kwan - Trends in neurosciences, 2021 - cell.com
Pilot studies have hinted that serotonergic psychedelics such as psilocybin may relieve
depression, and could possibly do so by promoting neural plasticity. Intriguingly, another …

Connectomes across development reveal principles of brain maturation

D Witvliet, B Mulcahy, JK Mitchell, Y Meirovitch… - Nature, 2021 - nature.com
An animal's nervous system changes as its body grows from birth to adulthood and its
behaviours mature,,,,,,–. The form and extent of circuit remodelling across the connectome is …

[HTML][HTML] Neuropathic pain caused by miswiring and abnormal end organ targeting

V Gangadharan, H Zheng, FJ Taberner, J Landry… - Nature, 2022 - nature.com
Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as
well as a loss of sensation in the areas in which injured and non-injured nerves come …

Spatial transcriptomics reveals the distinct organization of mouse prefrontal cortex and neuronal subtypes regulating chronic pain

A Bhattacherjee, C Zhang, BR Watson… - Nature …, 2023 - nature.com
The prefrontal cortex (PFC) is a complex brain region that regulates diverse functions
ranging from cognition, emotion and executive action to even pain processing. To decode …

Structure and function of axo-axonic inhibition

CM Schneider-Mizell, AL Bodor, F Collman, D Brittain… - Elife, 2021 - elifesciences.org
Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological,
molecular, and connectivity signatures. While considerable work has measured the average …

Dense neuronal reconstruction through X-ray holographic nano-tomography

AT Kuan - Biophysical Journal, 2020 - cell.com
1416-Pos Modulation of Human Stem Cell Derived Neuron Activity through Addition of an
External Conductance using Dynamic Clamp Brian K. Panama1, Leigh Korbel1, Brandon …

Postnatal connectomic development of inhibition in mouse barrel cortex

A Gour, KM Boergens, N Heike, Y Hua, P Laserstein… - Science, 2021 - science.org
INTRODUCTION The establishment of neuronal circuits in the cerebral cortex of mammals is
an important developmental process extending over embryonic and postnatal periods, from …