Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial
amount of research has been conducted to date to establish the anticancer potential of BBR …

Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer
activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects …

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Chemical compounds derived from plants have been used since the origin of human beings
to counteract a number of diseases. Among them, the natural isoquinoline alkaloid …

Alkaloids are used in traditional medicine for the treatment of many diseases. These
compounds are synthesized in plants as secondary metabolites and have multiple effects on …

Cancer is the most commonly diagnosed type of disease and a major cause of death
worldwide. Despite advancement in various treatment modules, there has been little …

Ethnopharmacological relevance The antineoplastic property of Coptidis Rhizoma and
berberine was correlated with its traditional use of clearing internal fire, removing damp-heat …

Breast cancer is the most common cancer among women worldwide and novel therapeutic
agents are needed to treat this disease. The plant-based alkaloid berberine has potential …

Introduction Anaplastic thyroid carcinoma (ATC) is the most lethal thyroid carcinoma.
Doxorubicin (DOX) is the only drug approved for anaplastic thyroid cancer treatment, but its …

Context• Having been used for thousands of years to treat gastrointestinal diseases, the
natural isoquinoline alkaloid, berberine, has exhibited a wide spectrum of biochemical and …