Applications of fluorine in medicinal chemistry

EP Gillis, KJ Eastman, MD Hill… - Journal of medicinal …, 2015 - ACS Publications
The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

Peptide-drug conjugates and their targets in advanced cancer therapies

P Hoppenz, S Els-Heindl, AG Beck-Sickinger - Frontiers in chemistry, 2020 - frontiersin.org
Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …

Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19

F De Virgiliis, S Di Giovanni - Nature Reviews Neurology, 2020 - nature.com
COVID-19 is an infectious disease caused by the coronavirus SARS-CoV-2, which was first
reported in Wuhan, China, in December 2019 and has caused a global pandemic. Acute …

Recent development of luminescent rhenium (I) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents

LCC Lee, KK Leung, KKW Lo - Dalton Transactions, 2017 - pubs.rsc.org
There has been fast-growing interest in the exploitation of the photophysical and
photochemical properties of luminescent transition metal complexes in biological …

[HTML][HTML] Radiolabeled peptides: valuable tools for the detection and treatment of cancer

M Fani, HR Maecke, SM Okarvi - Theranostics, 2012 - ncbi.nlm.nih.gov
Human cancer cells overexpress many peptide receptors as molecular targets.
Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor …

Targeted anticancer therapy: overexpressed receptors and nanotechnology

MJ Akhtar, M Ahamed, HA Alhadlaq, SA Alrokayan… - Clinica chimica acta, 2014 - Elsevier
Targeted delivery of anticancer drugs to cancer cells and tissues is a promising field due to
its potential to spare unaffected cells and tissues, but it has been a major challenge to …

Pediatric obesity: Current concepts

DE Greydanus, M Agana, MK Kamboj, S Shebrain… - Disease-a-Month, 2018 - Elsevier
This discussion reflects on concepts of obesity in children and adolescents in the early 21st
century. It includes reflections on its history, definition, epidemiology, diagnostic …

[图书][B] Intensive psychotherapy for persistent dissociative processes: the fear of feeling real (Norton series on interpersonal neurobiology)

RA Chefetz - 2015 - books.google.com
Winner of the International Society for the Study of Trauma and Dissociation's (ISSTD) Pierre
Janet Writing Award, 2015. What really happens in dissociation. Dissociative processes …

Peptide receptor radionuclide therapy: an overview

A Dash, S Chakraborty, MRA Pillai… - Cancer Biotherapy and …, 2015 - liebertpub.com
Peptide receptor radionuclide therapy (PRRT) is a site-directed targeted therapeutic strategy
that specifically uses radiolabeled peptides as biological targeting vectors designed to …

Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review

DP Prata, B Costa-Neves, G Cosme… - Journal of psychiatric …, 2019 - Elsevier
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …