Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion
of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of …

microRNAs (miRNAs) are a group of highly conserved small non-coding RNAs that were
found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating …

Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign
RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations …

ADAR1 is involved in adenosine-to-inosine RNA editing. The cytoplasmic ADAR1p150 edits
3'UTR double-stranded RNAs and thereby suppresses induction of interferons. Loss of this …

Members of the ADAR family of double-stranded RNA–binding proteins regulate one of the
most abundant RNA modifications in humans, the deamination of adenosine to inosine …

RNA editing is a cellular process that precisely alters nucleotide sequences, thus regulating
gene expression and generating protein diversity. Over 60% of human transcripts undergo …

RNAs are central to all gene expression through the control of protein synthesis. Four major
nucleosides, adenosine, guanosine, cytidine and uridine, compose RNAs and provide …

Both p150 and p110 isoforms of ADAR1 convert adenosine to inosine in double-stranded
RNA (dsRNA). ADAR1p150 suppresses the dsRNA-sensing mechanism that activates …

The birth of long non-coding RNAs (lncRNAs) is closely associated with the presence and
activation of repetitive elements in the genome. The transcription of endogenous …

RNA is modified by hundreds of chemical reactions and folds into innumerable shapes.
However, the regulatory role of RNA sequence and structure and how dysregulation leads to …