Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate
of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates …

Objectives Immunological dysregulation is now recognised as a major pathogenic event in
sepsis. Stimulation of immune response and immuno-modulation are emerging approaches …

Some people remain healthier throughout life than others but the underlying reasons are
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …

Objectives: To find and validate generalizable sepsis subtypes using data-driven clustering.
Design: We used advanced informatics techniques to pool data from 14 bacterial sepsis …

Improved risk stratification and prognosis prediction in sepsis is a critical unmet need.
Clinical severity scores and available assays such as blood lactate reflect global illness …

Improved identification of bacterial and viral infections would reduce morbidity from sepsis,
reduce antibiotic overuse, and lower healthcare costs. Here, we develop a generalizable …

Sepsis remains a leading cause of death for humans and currently has no pathogenesis-
specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic …

In order to explore the role of exosomal circRNAs in the occurrence and development of
sepsis, we looked for potential diagnostic markers to accurately identify sepsis and to lay a …

Background Sepsis is a life-threatening organ dysfunction caused by abnormal immune
responses to various, predominantly bacterial, infections. Different bacterial infections lead …

Background Interleukin-1 receptor associated kinase 3 (IRAK3) is a critical modulator of
inflammation and is associated with endotoxin tolerance and sepsis. Although IRAK3 is …