Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

Signaling cascades initiated by nitric oxide (NO) and natriuretic peptides (NPs) play an
important role in the maintenance of cardiovascular homeostasis. It is currently accepted that …

460 - Kuhn Page 1 Basic Res Cardiol 99: 76 – 82 (2004) DOI 10.1007/s00395-004-0460-0
FOCUSSED ISSUE: Natriuretic peptides Michaela Kuhn Molecular physiology of natriuretic …

Guanylin, uroguanylin, and the bacterial heat-stable enterotoxin (ST) peptides comprise a
new family of cyclic guanosine 3′-5′ monophosphate (cGMP)-regulating agonists. The …

Receptor Guanylyl Cyclase C (GC-C) was initially characterized as an important regulator of
intestinal fluid and ion homeostasis. Recent findings demonstrate that GC-C is also causally …

Guanylin and uroguanylin, peptides synthesized in the intestine and kidney, have been
postulated to have both paracrine and endocrine functions, forming a potential enteric-renal …

Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor.
Background Guanylin (GN) and uroguanylin (UGN) are intestinally derived peptide …

Enterotoxigenic Escherichia coli (ETEC) associated diarrhea is responsible for roughly half
a million deaths per year, the majority taking place in developing countries. The main agent …

Besides soluble guanylyl cyclase (GC), the receptor for NO, there are seven plasma
membrane forms of guanylyl cyclase (GC) receptors, enzymes that synthesize the second …

The natriuretic peptides (NPs) hormone family, which consists mainly of atrial, brain, and C-
type NPs (ANP, BNP, and CNP), play diverse roles in mammalian species, ranging from …