Evolving knowledge regarding sex differences in coronary heart disease is emerging. Given
the lower burden of obstructive coronary artery disease (CAD) and preserved systolic …

ContextMany women with angina are told that they have no significant heart disease
following demonstration of normal or near-normal coronary arteries and are offered no …

Abstract Purpose of Review Topical therapeutic approaches in localized neuropathic pain
(LNP) syndromes are increasingly used by both specialists and general practitioners, with a …

The interactions of the atypical antipsychotic drugs (APD) clozapine, olanzapine,
risperidone, quetiapine and ziprasidone with muscarinic receptors were reviewed. Only …

Severe chronic neuropathic pain is a challenge to treat, and due to adverse effects of
classical oral medication, optimal and effective dose levels are difficult to reach. Therefore …

Patients with persistent chest pain and no obstructive coronary artery disease are often
labeled as having noncardiac pain and not offered further cardiologic testing or treatment …

Background Amitriptyline, a tricyclic antidepressant, is frequently used orally for the
management of chronic pain. To date there is no report of amitriptyline producing peripheral …

Background and objectives Accumulating evidence indicates that amitriptyline decreases
pain sensation when administered orally, intraperitoneally, or for sciatic nerve block …

Background and Objectives The antidepressant amitriptyline is used as an adjuvant in the
treatment of a variety of chronic pain conditions. This drug interacts with many receptors and …

Rationale Schizophrenic patients show decreased measures of sensorimotor gating, such
as prepulse inhibition of startle (PPI). In preclinical models, these measures may be used to …