Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

The present review paper focuses on the chemistry of oxidative stress mitigation by
antioxidants. Oxidative stress is understood as a lack of balance between the pro-oxidant …

Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of
disrupting genome function, inducing genome instability and mutation. Such risks are due to …

Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Because telomeres shorten progressively with each replication, they …

Chronic inflammation is associated with normal and pathological ageing. Here we show that
chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the …

Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …

The epidemic of obesity is a major challenge for health policymakers due to its far-reaching
effects on population health and potentially overwhelming financial burden on healthcare …

Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Oxidative stress is the subject of numerous studies, most of them focusing on the negative
effects exerted at both molecular and cellular levels, ignoring the possible benefits of free …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …