Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
Pediatric hemophagocytic lymphohistiocytosis
SW Canna, RA Marsh - Blood, The Journal of the American …, 2020 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
[HTML][HTML] Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome
Background T cell mediated hyperinflammatory responses such as cytokine release
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …
Cytokine storm syndrome
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …
Histiocytic disorders
KL McClain, C Bigenwald, M Collin… - Nature Reviews …, 2021 - nature.com
The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …
diseases characterized by pathogenic myeloid cells that share histological features with …
Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: an open-label, single-centre, pilot trial
A Ahmed, SA Merrill, F Alsawah… - The Lancet …, 2019 - thelancet.com
Background Hemophagocytic lymphohistiocytosis is a cytokine-driven inflammatory
syndrome that is associated with substantial morbidity and mortality. Overall survival in adult …
syndrome that is associated with substantial morbidity and mortality. Overall survival in adult …
Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III …
B Shakoory, JA Carcillo, WW Chatham… - Critical care …, 2016 - journals.lww.com
Objective: To determine the efficacy of anakinra (recombinant interleukin-1 receptor
antagonist) in improving 28-day survival in sepsis patients with features of macrophage …
antagonist) in improving 28-day survival in sepsis patients with features of macrophage …
Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes
A subset of patients with severe COVID-19 develop profound inflammation and multi-organ
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare …
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare …
Hemophagocytic lymphohistiocytosis
H Al-Samkari, N Berliner - Annual review of pathology …, 2018 - annualreviews.org
Hemophagocytic lymphohistiocytosis is a life-threatening disorder characterized by
unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages …
unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages …
Hemophagocytic lymphohistiocytosis
Context.—Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder of
immune regulation that can eventually result in end-organ damage and death. HLH is …
immune regulation that can eventually result in end-organ damage and death. HLH is …