Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects
derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the …

Low nephron number—resulting, for example, from prematurity or developmental anomalies—
is a risk factor for the development of hypertension, chronic kidney disease and kidney …

The mechanisms underlying kidney development in mice and humans is an area of intense
study. Insights into kidney organogenesis have the potential to guide our understanding of …

The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that
could replenish functional homeostasis similarly to, eg, skin or the hematopoietic system …

Tissue boundaries and interfaces are engines of morphogenesis in vivo. However, despite a
wealth of micropatterning approaches available to control tissue size, shape, and …

Classically, trophic factors are considered as proteins which support neurons in their growth,
survival, and differentiation. However, most neurotrophic factors also have important …

Developmental biology-inspired strategies for tissue-building have extraordinary promise for
regenerative medicine, spurring interest in the relationship between cell biophysical …

Centrosomes are dominant microtubule organizing centers in animal cells with a pair of
centrioles at their core. They template cilia during interphase and help organize the mitotic …

Background MAPK/ERK signaling is a well-known mediator of extracellular stimuli
controlling intracellular responses to growth factors and mechanical cues. The critical …

The chemical and mechanical responses of cells via the exchange of information during
growth and development result in the formation of biological tissues. Information processing …