Quantum mechanics/molecular mechanics (QM/MM) hybrid models allow one to address
chemical phenomena in complex molecular environments. Whereas this modeling approach …

Voltage-dependent anion channel (VDAC), the most abundant mitochondrial outer
membrane protein, is important for a variety of mitochondrial functions including metabolite …

Diazirines are widely used in photoaffinity labeling (PAL) to trap noncovalent interactions
with biomolecules. However, design and interpretation of PAL experiments is challenging …

Ceramides draw wide attention as tumor suppressor lipids that act directly on mitochondria
to trigger apoptotic cell death. However, molecular details of the underlying mechanism are …

The translocator protein (TSPO), located at the outer mitochondrial membrane (OMM),
serves multiple functions and contributes to numerous processes, including cholesterol …

The voltage-dependent anion channel (VDAC) is a β-barrel membrane protein located in the
outer mitochondrial membrane (OMM). VDAC has two conductance states: an open anion …

Few antibiotics are effective against Acinetobacter baumannii, one of the most successful
pathogens responsible for hospital-acquired infections. Resistance to chlorhexidine, an …

Tools for on‐demand protein activation enable impactful gain‐of‐function studies in
biological settings. Thus far, however, proteins have been chemically caged at primarily Lys …

Mitochondria are double-membrane-bounded organelles that depend critically on
phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer …

Voltage-dependent anion channel (VDAC) is the major pathway for the transport of ions and
metabolites across the mitochondrial outer membrane. Among the three known mammalian …