The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …

The blood–brain barrier (BBB) is a selectively permeable membrane that separates the
bloodstream from the brain. While useful for protecting neural tissue from harmful …

Pulsed electric fields (PEFs) have become clinically important through the success of
Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs …

Electroporation is the process of instantaneously increasing the permeability of a cell
membrane under a pulsed electric field. Depending on the parameters of the electric pulses …

Pulsed electric fields interact with the blood–brain barrier (BBB) and have been shown to
increase the BBB permeability under some pulsing regimes. Pulsed electric fields may …

Irreversible electroporation (IRE) is a promising non-thermal treatment for inoperable tumors
which uses short (50–100 μs) high voltage monopolar pulses to disrupt the membranes of …

Background Pharmacological treatment of CNS diseases is limited due to the presence of
the blood-brain barrier (BBB). Recent years showed significant advancement in the field of …

Abstract Electroporation-based therapy (EBT), as a high-voltage-pulse technology has been
prevalent with favorable clinical outcomes in the treatment of various solid tumors. This …

The blood–brain barrier (BBB) is limiting transcellular and paracellular movement of
molecules and cells, controls molecular traffic, and keeps out toxins. However, this protective …

Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug
concentrations due to protection from the blood–brain barrier (BBB). Electroporation-based …