[HTML][HTML] Methods for measuring pharyngeal behaviors

D Raizen, B Song, N Trojanowski… - WormBook: The Online …, 2018 - ncbi.nlm.nih.gov
The pharynx is a neuromuscular pump at the anterior end of the alimentary tract. It is made
up of 20 muscle cells, 20 neurons, and 20 other cells. Pharyngeal activity correlates with …

Microfluidics in High-Throughput Drug Screening: Organ-on-a-Chip and C. elegans-Based Innovations

S Yoon, D Kilicarslan You, U Jeong, M Lee, E Kim… - Biosensors, 2024 - mdpi.com
The development of therapeutic interventions for diseases necessitates a crucial step known
as drug screening, wherein potential substances with medicinal properties are rigorously …

A brainstem integrator for self-location memory and positional homeostasis in zebrafish

E Yang, MF Zwart, B James, M Rubinov, Z Wei… - Cell, 2022 - cell.com
To track and control self-location, animals integrate their movements through space.
Representations of self-location are observed in the mammalian hippocampal formation, but …

Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels

N Pokala, Q Liu, A Gordus… - Proceedings of the …, 2014 - National Acad Sciences
Recent progress in neuroscience has been facilitated by tools for neuronal activation and
inactivation that are orthogonal to endogenous signaling systems. We describe here a …

[HTML][HTML] Flexible and disposable paper-and plastic-based gel micropads for nematode handling, imaging, and chemical testing

Z Njus, T Kong, U Kalwa, C Legner, M Weinstein… - APL …, 2017 - pubs.aip.org
Today, the area of point-of-care diagnostics is synonymous with paper microfluidics where
cheap, disposable, and on-the-spot detection toolkits are being developed for a variety of …

Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG

YB Qi, EJ Garren, X Shu… - Proceedings of the …, 2012 - National Acad Sciences
We describe a method for light-inducible and tissue-selective cell ablation using a
genetically encoded photosensitizer, miniSOG (mini singlet oxygen generator). miniSOG is a …

Working with Worms: Caenorhabditis elegans as a Model Organism

PM Meneely, CL Dahlberg… - Current Protocols …, 2019 - Wiley Online Library
Since its introduction as a laboratory organism 50 years ago, the nematode worm
Caenorhabditis elegans has become one of the most widely used and versatile models for …

Plasticity of the electrical connectome of C. elegans

A Bhattacharya, U Aghayeva, EG Berghoff, O Hobert - Cell, 2019 - cell.com
The specific patterns and functional properties of electrical synapses of a nervous system
are defined by the neuron-specific complement of electrical synapse constituents. We …

An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans

M Turek, I Lewandrowski, H Bringmann - Current Biology, 2013 - cell.com
Background Sleep is an essential behavior that is found in all animals that have a nervous
system. Neural activity is thought to control sleep, but little is known about the identity and …

Sex-specific pruning of neuronal synapses in Caenorhabditis elegans

M Oren-Suissa, EA Bayer, O Hobert - Nature, 2016 - nature.com
Whether and how neurons that are present in both sexes of the same species can
differentiate in a sexually dimorphic manner is not well understood. A comparison of the …