Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Chromosome segregation errors during cell divisions generate aneuploidies and
micronuclei, which can undergo extensive chromosomal rearrangements such as …

Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men globally. CRC arises from one or a combination of chromosomal instability …

Background Clinical studies regarding colorectal cancer (CRC) have suggested differences
in metastatic patterns between mucinous adenocarcinoma (MC), signet-ring cell carcinoma …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Chromosomal aberrations during cell division represent one of the first recognized features
of human cancer cells, and modern detection methods have revealed the pervasiveness of …