Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

The microbiome and human cancer

GD Sepich-Poore, L Zitvogel, R Straussman, J Hasty… - Science, 2021 - science.org
BACKGROUND Historical accounts linking cancer and microbes date as early as four
millennia ago. After establishment of the germ theory of infectious diseases, clinical research …

Screening and prevention of colorectal cancer

P Kanth, JM Inadomi - Bmj, 2021 - bmj.com
Mortality from colorectal cancer is reduced through screening and early detection; moreover,
removal of neoplastic lesions can reduce cancer incidence. While understanding of the risk …

Microbiome analyses of blood and tissues suggest cancer diagnostic approach

GD Poore, E Kopylova, Q Zhu, C Carpenter… - Nature, 2020 - nature.com
Systematic characterization of the cancer microbiome provides the opportunity to develop
techniques that exploit non-human, microorganism-derived molecules in the diagnosis of a …

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

SH Wong, J Yu - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …

Dysbiosis of human gut microbiome in young-onset colorectal cancer

Y Yang, L Du, D Shi, C Kong, J Liu, G Liu, X Li… - Nature …, 2021 - nature.com
The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant
knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients …

Colorectal cancer in the young: epidemiology, prevention, management.

RL Siegel, CD Jakubowski, SA Fedewa… - American Society of …, 2020 - europepmc.org
Colorectal cancer (CRC) incidence rates in the United States overall have declined since
the mid-1980s because of changing patterns in risk factors (eg, decreased smoking) and …

New insights into gut-bacteria-derived indole and its derivatives in intestinal and liver diseases

X Li, B Zhang, Y Hu, Y Zhao - Frontiers in Pharmacology, 2021 - frontiersin.org
The interaction between host and microorganism widely affects the immune and metabolic
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …

[HTML][HTML] Prevalence and risk factors of colorectal cancer in Asia

MCS Wong, H Ding, J Wang, PSF Chan… - Intestinal …, 2019 - synapse.koreamed.org
Globally, colorectal cancer (CRC) is a substantial public health burden, and it is increasingly
affecting populations in Asian countries. The overall prevalence of CRC is reported to be low …

The microbiota and microbiome in pancreatic cancer: more influential than expected

MY Wei, S Shi, C Liang, QC Meng, J Hua, YY Zhang… - Molecular cancer, 2019 - Springer
Microbiota is just beginning to be recognized as an important player in carcinogenesis and
the interplay among microbes is greater than expected. Pancreatic ductal adenocarcinoma …