Mother or father: who is in the front line? Mechanisms underlying the non-genomic transmission of obesity/diabetes via the maternal or the paternal line
B Portha, V Grandjean, J Movassat - Nutrients, 2019 - mdpi.com
Extensive epidemiological and experimental evidence have shown that exposure to an
adverse intrauterine environment as observed in offspring of pregnancies complicated by …
adverse intrauterine environment as observed in offspring of pregnancies complicated by …
Does exposure to hyperglycaemia in utero increase the risk of obesity and diabetes in the offspring? A critical reappraisal
LE Donovan, T Cundy - Diabetic Medicine, 2015 - Wiley Online Library
Background The idea that exposure to hyperglycaemia in utero is an important factor in the
development of obesity and diabetes in the offspring has become entrenched as popular …
development of obesity and diabetes in the offspring has become entrenched as popular …
Temporal transcriptomic and proteomic landscapes of deteriorating pancreatic islets in type 2 diabetic rats
Progressive reduction in β-cell mass and function comprise the core of the pathogenesis
mechanism of type 2 diabetes. The process of deteriorating pancreatic islets, in which a …
mechanism of type 2 diabetes. The process of deteriorating pancreatic islets, in which a …
Maternal diabetes, programming of beta-cell disorders and intergenerational risk of type 2 diabetes
A Chavey, MDA Kioon, D Bailbé, J Movassat… - Diabetes & …, 2014 - Elsevier
A substantial body of evidence suggests that an abnormal intra-uterine milieu elicited by
maternal metabolic disturbances as diverse as malnutrition, placental insufficiency, diabetes …
maternal metabolic disturbances as diverse as malnutrition, placental insufficiency, diabetes …
RNA-seq analysis of the hypothalamic transcriptome reveals the networks regulating physiopathological progress in the diabetic GK rat
Y Meng, Y Guan, W Zhang, Y Wu, H Jia, Y Zhang… - Scientific reports, 2016 - nature.com
Abstract The Goto-Kakizaki (GK) rat is an animal model of non-obese type 2 diabetes (T2D).
The GK rat was generated through the introduction of various genetic mutations from …
The GK rat was generated through the introduction of various genetic mutations from …
Effect of postnatal nutritional environment due to maternal diabetes on beta cell mass programming and glucose intolerance risk in male and female offspring
D Bailbe, J Liu, P Gong, B Portha - Biomolecules, 2021 - mdpi.com
Besides the fetal period, the suckling period is a critical time window in determining long-
term metabolic health. We undertook the present study to elucidate the impact of a diabetic …
term metabolic health. We undertook the present study to elucidate the impact of a diabetic …
Integrative analysis of genome and expression profile data reveals the genetic mechanism of the diabetic pathogenesis in Goto Kakizaki (GK) rats
Y Meng, Y Cui, W Zhang, S Fu, L Huang, H Dong… - Frontiers in …, 2019 - frontiersin.org
The Goto Kakizaki (GK) rats which can spontaneously develop type 2 diabetes (T2D), are
generated by repeated inbreeding of Wistar rats with glucose intolerance. The glucose …
generated by repeated inbreeding of Wistar rats with glucose intolerance. The glucose …