The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Breast cancer is one of the most prevalent malignant diseases, and one of the main causes
of mortality among women across the world. Despite advances in chemotherapy, drug …

Drug candidates are generally discovered using biochemical screens employing an isolated
target protein or by utilizing cell-based phenotypic assays. Both noncovalent and covalent …

Chemo-resistance is a huge obstacle encountered in the osteosarcoma (OS) treatment.
Protein-coding mRNAs, as well as non-coding RNAs (ncRNAs), including long ncRNA …

Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-
cysteinylglycine and the predominant intracellular antioxidant in many organisms including …

We describe an efficient one-pot procedure that “folds” acyclic triketones into structurally
complex, pharmaceutically relevant tricyclic systems that combine high oxygen content with …

An original strategy toward bridged tetraoxazaspirobicycloalkanes was developed. The
synthesis is based on a three-component condensation–cyclization reaction of primary …

An efficient and practical method has been developed for the facile synthesis of 1, 2, 4‐
trioxanes by the condensation of β‐hydroperoxy alcohols and carbonyl compounds in the …

Indium‐catalyzed sequential remote C− H functionalization (C‐6 position) and C3‐
indolylation of peroxyoxindole using indole is described for the synthesis of terindolinone …

Using reported glutathione S-transferase omega 1 (GSTO1-1) cocrystal structures, we
designed and synthesized acrylamide-containing compounds that covalently bind to Cys32 …