Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

The development and survival of all organisms depends on equal partitioning of their
genomes during cell division. Accurate chromosome segregation requires selective …

Mitotic cells face the challenging task of ensuring accurate and equal segregation of their
duplicated, condensed chromosomes between the nascent daughter cells. Errors in the …

The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to
the state of attachment of the kinetochore to spindle microtubules. SAC signalling is …

Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of
cancer and linked to cancer genome evolution. Errors can manifest as" lagging …

Summary The Mps1 and Aurora B kinases regulate and monitor kinetochore attachment to
spindle microtubules during cell division, ultimately ensuring accurate chromosome …

Abstract The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved
kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for …

The eukaryotic cell division machinery must rapidly and reproducibly duplicate and partition
the cell's chromosomes in a carefully coordinated process. However, chromosome numbers …

Individuals carrying an aberrant number of chromosomes can vary widely in their expression
of aneuploidy phenotypes. A major unanswered question is the degree to which an …

During mitosis and meiosis, sister chromatid cohesion resists the pulling forces of
microtubules, enabling the generation of tension at kinetochores upon chromosome …