Label-free characterization of white blood cells using fluorescence lifetime imaging and flow-cytometry: molecular heterogeneity and erythrophagocytosis

BP Yakimov, MA Gogoleva, AN Semenov… - Biomedical optics …, 2019 - opg.optica.org
Blood cell analysis is one of the standard clinical tests. Despite the widespread use of
exogenous markers for blood cell quantification, label-free optical methods are still of high …

Exoscope-based videocapillaroscopy system for in vivo skin microcirculation imaging of various body areas

AS Machikhin, MV Volkov, DD Khokhlov… - Biomedical Optics …, 2021 - opg.optica.org
The capillary system immediately responds to many pathologies and environmental
conditions. Accurate monitoring of its functioning often enables early detection of various …

DA-Capnet: dual attention deep learning based on U-Net for nailfold capillary segmentation

YS Hariyani, H Eom, C Park - IEEE Access, 2020 - ieeexplore.ieee.org
Automatic nailfold capillary segmentation is a challenging task owing to noise and large
variabilities in images caused by insufficient focusing and low visibility of the capillaries. This …

Visualization of blood cell contrast in nailfold capillaries with high-speed reverse lens mobile phone microscopy

GN McKay, N Mohan, I Butterworth… - Biomedical optics …, 2020 - opg.optica.org
Quantification of optical absorption gaps in nailfold capillaries has recently shown promise
as a non-invasive technique for neutropenia screening. Here we demonstrate a low-cost …

Imaging human blood cells in vivo with oblique back-illumination capillaroscopy

GN McKay, N Mohan, NJ Durr - Biomedical optics express, 2020 - opg.optica.org
We present a non-invasive, label-free method of imaging blood cells flowing through human
capillaries in vivo using oblique back-illumination capillaroscopy (OBC). Green light …

In-vivo full-field measurement of microcirculatory blood flow velocity based on intelligent object identification

F Ye, S Yin, M Li, Y Li, J Zhong - Journal of biomedical optics, 2020 - spiedigitallibrary.org
Microcirculation plays a crucial role in delivering oxygen and nutrients to living tissues and
in removing metabolic wastes from the human body. Monitoring the velocity of blood flow in …

Segmenting nailfold capillaries using an improved U-net network

S Liu, Y Li, J Zhou, J Hu, N Chen, Y Shang… - Microvascular …, 2020 - Elsevier
To assess the microcirculation in a patient's capillaries, clinicians often use the valuable and
non-invasive diagnostic tool of nailfold capillaroscopy (NC). In particular, evaluating the …

[HTML][HTML] Impact of lymphocyte and neutrophil counts on mortality risk in severe community-acquired pneumonia with or without septic shock

E Güell, M Martín-Fernandez, MC De la Torre… - Journal of clinical …, 2019 - mdpi.com
Background: Community-acquired pneumonia (CAP) is a frequent cause of death
worldwide. As recently described, CAP shows different biological endotypes. Improving …

A deep learning bidirectional temporal tracking algorithm for automated blood cell counting from non-invasive capillaroscopy videos

L Huang, GN McKay, NJ Durr - … , France, September 27–October 1, 2021 …, 2021 - Springer
Oblique back-illumination capillaroscopy has recently been introduced as an efficient
method for non-invasive blood cell imaging in human capillaries. To apply this technique to …

Label-free automated neutropenia detection and grading using deep-ultraviolet microscopy

A Ojaghi, P Casteleiro Costa, C Caruso… - Biomedical optics …, 2021 - opg.optica.org
Neutropenia is a condition identified by an abnormally low number of neutrophils in the
bloodstream and signifies an increased risk of severe infection. Cancer patients are …