The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …

Extracellular vesicles (EVs) may mediate intercellular communication by carrying protein
and RNA cargo. The composition, biology, and roles of EVs in physiology and pathology …

Lipid droplets are ubiquitous cellular organelles that allow cells to store large amounts of
neutral lipids for membrane synthesis and energy supply in times of starvation. Compared to …

A growing body of evidence indicates that gut microbiota influence brain function and
behaviour. However, the molecular basis of how gut bacteria modulate host nervous system …

Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity
through conserved homeostatic mechanisms. Here we report an exceptionally large and …

Background Animal models are indispensable to understand the lipid metabolism and lipid
metabolic diseases. Over the last decade, the nematode Caenorhabditis elegans has …

Microorganisms and their hosts share the same environment, and microbial metabolic
molecules (metabolites) exert crucial effects on host physiology. Environmental factors not …