A functional immune system requires the selection of T lymphocytes expressing receptors
that are major histocompatibility complex restricted but tolerant to self-antigens. This …

The cells of both the adaptive and innate immune systems express a dizzying array of
receptors that transduce and integrate an enormous amount of information about the …

Activation of extracellular-signal-regulated protein kinase (Erk) is central to growth-factor-
receptor-mediated signaling including that originating from the T cell antigen receptor. It …

The observation that the TCR, BCR, and some Fc receptors are associated with multiple
ITAM-signaling subunits suggests that these subunits support the efficient signal …

T lymphocytes are generated in the thymus, where developing thymocytes must accept one
of two fates: They either differentiate or they die. These fates are chiefly determined by …

T cells have an amazing ability to discern and differentially respond to MHC-embedded
peptides that can differ by only a single amino acid. This potential involves a combination of …

During development, discrete cell fates often result from variation in the intensity of a
particular signal. The mechanisms underlying these seemingly analog-to-digital switches …

The extraordinary sensitivity of CD8+ T cells to recognize antigen impinges to a large extent
on the coreceptor CD8. While several studies have shown that the CD8β chain endows CD8 …

The series of events leading to T‐cell activation following antigen recognition has been
extensively investigated. Although the exact mechanisms of ligand binding and transmission …

We investigated the molecular mechanism underlying a severe combined immunodeficiency
characterized by the selective and complete absence of T cells. The condition was found in …