The most life-threatening aspects of the oncogenic process are invasion and metastasis.
Even though the clinical significance of such expression of the malignant phenotype has …

Metastasis is the major cause of morbidity and death for cancer patients. Treatment
modalities such as surgery, chemo therapy, and radiotherapy can now cure approximately …

We have reconstituted a matrix of basement membrane onto a filter in a Boyden chamber
and assessed the ability of various malignant and nonmalignant cells to penetrate through …

We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA
levels were highest in cells and tumors of relatively low metastatic potential in two …

Oncogene mutations are frequently found in several tumour types and, among these, point
mutations of the ras gene are particularly significant. A predominance of N‐ras mutations …

A group of coordinated cellular processes, not just one gene product, is responsible for
invasion and metastasis, the most life-threatening aspect of cancer. It is now recognized that …

The search for genetic damage in neoplastic cells now occupies a central place in cancer
research. Diverse examples of such damage are in hand, and they in turn hint at …

Publisher Summary This chapter discusses the inefficiency of different steps of metastasis
against both numerical and temporal backgrounds. The chapter also deals with the …

The differential expression of the ras oncogene product p21 in the primary tumor, regional
nodes, and distant metastatic sites in patients with disseminated breast cancer was …

Trop-2 is a calcium signal transducer that is associated with transformed cell growth in
experimental systems. However, its role in human cancer remains essentially unknown. In …