Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …

Neutrophils are immune cells with unusual biological features that furnish potent
antimicrobial properties. These cells phagocytose and subsequently kill prokaryotic and …

Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

As one of the first defenders of innate immune response, neutrophils make a rapid and
robust response against infection or harmful agents. While traditionally regarded as suicidal …

Immunological niches are focal sites of immune activity that can have varying
microenvironmental features. Hypoxia is a feature of physiological and pathological …

The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

Interactions between the microbiota and distal gut are fundamental determinants of human
health. Such interactions are concentrated at the colonic mucosa and provide energy for the …

An effective resolution program may be able to prevent the progression from non-resolving
acute inflammation to persistent chronic inflammation. It has now become evident that …

Neutrophils promptly accumulate in large numbers at sites of tissue injury. Injuries to the skin
or mucosae disrupt barriers against the external environment, and the bactericidal actions of …