Apoptosis, necroptosis, and pyroptosis are genetically programmed cell death mechanisms
that eliminate obsolete, damaged, infected, and self-reactive cells. Apoptosis fragments cells …

Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

Bromodomains are protein-protein interaction modules with a great diversity in terms of
number of proteins and their function. The bromodomain and extraterminal protein (BET) …

BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …

Double/triple-hit lymphomas (DHL/THL) account for 5–10% of diffuse large B cell lymphoma
(DLBCL) with rearrangement of MYC and BCL2 and/or BCL6 resulting in MYC …

Despite considerable advances in the treatment of lymphoma, the prognosis of patients with
relapsed and/or refractory disease continues to be poor; thus, a continued need exists for …

Acute myeloid leukemias (AML) with mutations in the NPM1 gene (NPM1c+) represent a
large AML subgroup with varying response to conventional treatment, highlighting the need …

Abstract The Bromo-and Extra-Terminal domain (BET) family proteins act as “readers” of
acetylated histones and they are important transcription regulators. BRD2, BRD3, BRD4 and …

Local adaptation directs populations towards environment-specific fitness maxima through
acquisition of positively selected traits. However, rapid environmental changes can identify …

Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin's
lymphoma (NHL). 30~ 40% of DLBCL patients were resistant to the standard R-CHOP …