Therapeutic peptides: current applications and future directions

L Wang, N Wang, W Zhang, X Cheng, Z Yan… - Signal transduction and …, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy

AM Angelidi, MJ Belanger, A Kokkinos… - Endocrine …, 2022 - academic.oup.com
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

Proglucagon-derived peptides as therapeutics

RA Lafferty, FPM O'Harte, N Irwin, VA Gault… - Frontiers in …, 2021 - frontiersin.org
Initially discovered as an impurity in insulin preparations, our understanding of the
hyperglycaemic hormone glucagon has evolved markedly over subsequent decades. With …

The implication of gut hormones in the regulation of energy homeostasis and their role in the pathophysiology of obesity

C Koliaki, S Liatis, M Dalamaga, A Kokkinos - Current obesity reports, 2020 - Springer
Abstract Purpose of Review This review provides an update on the role of gut hormones and
their interactions in the regulation of energy homeostasis, describes gut hormone …

Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond

D Tsilingiris, A Kokkinos - Metabolism, 2024 - Elsevier
Currently, metabolic surgery (MS) constitutes the most effective means for durable weight
loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non …

[HTML][HTML] Equine metabolic syndrome: role of the enteroinsular axis in the insulin response to oral carbohydrate

MA de Laat, DM Fitzgerald - The Veterinary Journal, 2023 - Elsevier
Equine insulin dysregulation (ID) comprises amplified insulin responses to oral
carbohydrates or insulin resistance, or both, which leads to sustained or periodic …

Circulating levels of gastrointestinal hormones in response to the most common types of bariatric surgery and predictive value for weight loss over one year: evidence …

N Perakakis, A Kokkinos, N Peradze, N Tentolouris… - Metabolism, 2019 - Elsevier
Aims Bariatric surgery leads to profound and sustainable weight loss. Gastrointestinal
hormones are involved in energy and glucose homeostasis, thus postoperative changes of …

An overview of obesity mechanisms in humans: Endocrine regulation of food intake, eating behaviour and common determinants of body weight

S Theilade, MB Christensen, T Vilsbøll… - Diabetes, Obesity and …, 2021 - Wiley Online Library
Obesity is one of the biggest health challenges of the 21st century, already affecting close to
700 million people worldwide, debilitating and shortening lives and costing billions of …

Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss

MS Nielsen, C Ritz… - The Journal of …, 2020 - academic.oup.com
Background Alterations in several gastrointestinal hormones are implicated in the
postoperative suppression of food intake leading to weight loss after Roux-en-Y gastric …

Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity

SA Kleftaki, S Simati, C Amerikanou, A Gioxari… - Pharmacological …, 2022 - Elsevier
The aim of this study was to examine potential postprandial benefits of Pleurotus eryngii in
nineteen volunteers with metabolically unhealthy obesity. An acute, randomized, crossover …