Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

The state of the art on acetylcholinesterase inhibitors in the treatment of Alzheimer's disease

I Vecchio, L Sorrentino, A Paoletti… - Journal of Central …, 2021 - journals.sagepub.com
Alzheimer's disease (AD) is a chronic disabling disease that affects the central nervous
system. The main consequences of AD include the decline of cognitive functions and …

[HTML][HTML] Glucagon-like peptide-1: A multi-faceted anti-inflammatory agent

SF Mehdi, S Pusapati, MS Anwar, D Lohana… - Frontiers in …, 2023 - frontiersin.org
Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …

[HTML][HTML] The complex role of inflammation and gliotransmitters in Parkinson's disease

A Gopinath, PM Mackie, LT Phan, MG Tansey… - Neurobiology of …, 2023 - Elsevier
Our understanding of the role of innate and adaptive immune cell function in brain health
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …

Cholinergic modulation of the immune system in neuroinflammatory diseases

M Reale, E Costantini - Diseases, 2021 - mdpi.com
Frequent diseases of the CNS, such as Alzheimer's disease, Parkinson's disease, multiple
sclerosis, and psychiatric disorders (eg, schizophrenia), elicit a neuroinflammatory response …

[Retracted] Intestinal Flora Balance Therapy Based on Probiotic Support Improves Cognitive Function and Symptoms in Patients with Alzheimer's Disease: A …

C Liu, X Guo, X Chang - BioMed Research International, 2022 - Wiley Online Library
Objective. The clinical value of intestinal flora balance therapy based on probiotic support in
improving cognitive function and symptoms of patients with Alzheimer's disease was to …

Inflammatory animal models of Parkinson's disease

J García-Revilla, AJ Herrera… - Journal of …, 2022 - content.iospress.com
Accumulating evidence suggests that microglia and peripheral immune cells may play
determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a …

Novel insights into the emerging role of Neat1 and its effects downstream in the regulation of inflammation

Y Pan, T Wang, Z Zhao, W Wei, X Yang… - Journal of …, 2022 - Taylor & Francis
Nuclear paraspeckle assembly transcript 1 (Neat1) located at chromosome 11 is a long non-
coding RNA that is widely expressed in mammalian cell types, and which is overexpressed …

Novel Neuroprotective Potential of Bunchosia armeniaca (Cav.) DC against Lipopolysaccharide Induced Alzheimer's Disease in Mice

HA Abbas, AM Salama, SA El-Toumy, AA A. Salama… - Plants, 2022 - mdpi.com
Bunchosia armeniaca (Cav.) DC (Malpighiaceae) is one of the well-known traditionally used
remedies worldwide. This study aims to explore the leaves' metabolome via Quadrupole …

Coffee polyphenol, chlorogenic acid, suppresses brain aging and its effects are enhanced by milk fat globule membrane components

K Unno, K Taguchi, T Hase, S Meguro… - International Journal of …, 2022 - mdpi.com
Mice feed with coffee polyphenols (CPP, chlorogenic acid) and milk fat globule membrane
(MFGM) has increased survival rates and helps retain long-term memory. In the cerebral …