What made sesquiterpene lactones reach cancer clinical trials?
A Ghantous, H Gali-Muhtasib, H Vuorela, NA Saliba… - Drug discovery today, 2010 - Elsevier
Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional
medicine against inflammation and cancer. This review focuses on the chemical and …
medicine against inflammation and cancer. This review focuses on the chemical and …
[HTML][HTML] Feverfew (Tanacetum parthenium L.): A systematic review
A Pareek, M Suthar, GS Rathore… - Pharmacognosy …, 2011 - ncbi.nlm.nih.gov
Abstract Feverfew (Tanacetum parthenium L.)(Asteraceae) is a medicinal plant traditionally
used for the treatment of fevers, migraine headaches, rheumatoid arthritis, stomach aches …
used for the treatment of fevers, migraine headaches, rheumatoid arthritis, stomach aches …
Biological activities of sesquiterpene lactones
AK Picman - Biochemical systematics and Ecology, 1986 - Elsevier
Although sesquiterpene lactones are terpenoid compounds characteristic of the Asteraceae
(Compositae) they are also known from other angiosperm families as well as from some …
(Compositae) they are also known from other angiosperm families as well as from some …
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase
BHB Kwok, B Koh, MKI Ndubuisi, M Elofsson… - Chemistry & biology, 2001 - cell.com
Background: Biologically active natural products continue to be useful in the exploration and
control of intracellular signaling processes. For example, the sesquiterpene lactone …
control of intracellular signaling processes. For example, the sesquiterpene lactone …
In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa
JY Cho, KU Baik, JH Jung, MH Park - European Journal of Pharmacology, 2000 - Elsevier
We investigated in vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone
from Saussurea lappa, on tumor necrosis factor (TNF)-α and nitric oxide (NO) release, and …
from Saussurea lappa, on tumor necrosis factor (TNF)-α and nitric oxide (NO) release, and …
Perspectives on sesquiterpene lactones in inflammation and cancer
I Merfort - Current drug targets, 2011 - ingentaconnect.com
Sesquiterpene lactones are a large group of secondary plant metabolites mostly known from
the Asteraceae family. They exert a broad variety of different biological activities. This review …
the Asteraceae family. They exert a broad variety of different biological activities. This review …
Oxidative stress-mediated apoptosis: the anticancer effect of the sesquiterpene lactone parthenolide
J Wen, KR You, SY Lee, CH Song, DG Kim - Journal of Biological …, 2002 - ASBMB
The sesquiterpene lactone parthenolide, the principal active component in medicinal plants,
has been used conventionally to treat migraines, inflammation, and tumors. However, the …
has been used conventionally to treat migraines, inflammation, and tumors. However, the …
Quantitative structure− activity relationship of sesquiterpene lactones as inhibitors of the transcription Factor NF-κB
B Siedle, AJ García-Piñeres, R Murillo… - Journal of medicinal …, 2004 - ACS Publications
Sesquiterpene lactones (SLs) are the active compounds of a variety of tradionally used
medicinal plants from the Asteraceae family. They are known to possess a considerable …
medicinal plants from the Asteraceae family. They are known to possess a considerable …
Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice
A Wesołowska, A Nikiforuk, K Michalska… - Journal of …, 2006 - Elsevier
Lactucin (1) and its derivatives lactucopicrin (2) and 11β, 13-dihydrolactucin (3), which are
characteristic bitter sesquiterpene lactones of Lactuca virosa and Cichorium intybus, were …
characteristic bitter sesquiterpene lactones of Lactuca virosa and Cichorium intybus, were …
Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-κB inhibitor, DMAPT (LC-1)
S Neelakantan, S Nasim, ML Guzman… - Bioorganic & medicinal …, 2009 - Elsevier
A series of aminoparthenolide analogs (6–37) were synthesized and evaluated for their anti-
leukemic activity. Eight compounds exhibited good anti-leukemic activity with LD50's in the …
leukemic activity. Eight compounds exhibited good anti-leukemic activity with LD50's in the …