What made sesquiterpene lactones reach cancer clinical trials?

A Ghantous, H Gali-Muhtasib, H Vuorela, NA Saliba… - Drug discovery today, 2010 - Elsevier
Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional
medicine against inflammation and cancer. This review focuses on the chemical and …

[HTML][HTML] Feverfew (Tanacetum parthenium L.): A systematic review

A Pareek, M Suthar, GS Rathore… - Pharmacognosy …, 2011 - ncbi.nlm.nih.gov
Abstract Feverfew (Tanacetum parthenium L.)(Asteraceae) is a medicinal plant traditionally
used for the treatment of fevers, migraine headaches, rheumatoid arthritis, stomach aches …

Biological activities of sesquiterpene lactones

AK Picman - Biochemical systematics and Ecology, 1986 - Elsevier
Although sesquiterpene lactones are terpenoid compounds characteristic of the Asteraceae
(Compositae) they are also known from other angiosperm families as well as from some …

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase

BHB Kwok, B Koh, MKI Ndubuisi, M Elofsson… - Chemistry & biology, 2001 - cell.com
Background: Biologically active natural products continue to be useful in the exploration and
control of intracellular signaling processes. For example, the sesquiterpene lactone …

In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa

JY Cho, KU Baik, JH Jung, MH Park - European Journal of Pharmacology, 2000 - Elsevier
We investigated in vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone
from Saussurea lappa, on tumor necrosis factor (TNF)-α and nitric oxide (NO) release, and …

Perspectives on sesquiterpene lactones in inflammation and cancer

I Merfort - Current drug targets, 2011 - ingentaconnect.com
Sesquiterpene lactones are a large group of secondary plant metabolites mostly known from
the Asteraceae family. They exert a broad variety of different biological activities. This review …

Oxidative stress-mediated apoptosis: the anticancer effect of the sesquiterpene lactone parthenolide

J Wen, KR You, SY Lee, CH Song, DG Kim - Journal of Biological …, 2002 - ASBMB
The sesquiterpene lactone parthenolide, the principal active component in medicinal plants,
has been used conventionally to treat migraines, inflammation, and tumors. However, the …

Quantitative structure− activity relationship of sesquiterpene lactones as inhibitors of the transcription Factor NF-κB

B Siedle, AJ García-Piñeres, R Murillo… - Journal of medicinal …, 2004 - ACS Publications
Sesquiterpene lactones (SLs) are the active compounds of a variety of tradionally used
medicinal plants from the Asteraceae family. They are known to possess a considerable …

Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice

A Wesołowska, A Nikiforuk, K Michalska… - Journal of …, 2006 - Elsevier
Lactucin (1) and its derivatives lactucopicrin (2) and 11β, 13-dihydrolactucin (3), which are
characteristic bitter sesquiterpene lactones of Lactuca virosa and Cichorium intybus, were …

Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-κB inhibitor, DMAPT (LC-1)

S Neelakantan, S Nasim, ML Guzman… - Bioorganic & medicinal …, 2009 - Elsevier
A series of aminoparthenolide analogs (6–37) were synthesized and evaluated for their anti-
leukemic activity. Eight compounds exhibited good anti-leukemic activity with LD50's in the …