Mitochondrial diseases are a group of genetic disorders characterized by dysfunctional
mitochondria. Within eukaryotic cells, mitochondria contain their own ribosomes, which …

The mitochondrial disease group consists of different disorders with unprecedented
variability of clinical manifestations and tissue-specific symptoms. Their tissue-specific stress …

Background Mitochondria participate in various cellular processes including energy
metabolism, apoptosis, autophagy, production of reactive oxygen species, stress responses …

The complex dynamics and transience of assembly pathways in living systems complicate
the understanding of these molecular to nanoscale processes. Current technologies are …

The major criterion that distinguishes eukaryotes from prokaryotes is the presence of
organelles in the former. Organelles provide a compartment in which biochemical processes …

The process of embryonic development involves remarkable cellular plasticity, which
governs the coordination between cells necessary to build an organism. One role of this …

The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

The accumulation of senescent cells in the aging individual is associated with an increase in
the occurrence of age-associated pathologies that contribute to poor health, frailty, and …

Mitochondrial genetic defects caused by whole-body mutations typically affect different
tissues in different ways. Elucidating the molecular determinants that cause certain cell types …

Parkinson's disease (PD) is a common and incurable neurodegenerative disorder that
arises from the loss of dopaminergic neurons in the substantia nigra and is mainly …