Clinical course and management of COVID-19 in the era of widespread population immunity

EA Meyerowitz, J Scott, A Richterman, V Male… - Nature Reviews …, 2024 - nature.com
The clinical implications of COVID-19 have changed since SARS-CoV-2 first emerged in
humans. The current high levels of population immunity, due to prior infection and/or …

Treatments for COVID-19

HS Andrews, JD Herman… - Annual Review of …, 2024 - annualreviews.org
The treatment for COVID-19 has evolved rapidly since the start of the pandemic and now
consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir …

Real-world COVID-19 vaccine effectiveness against the Omicron BA. 2 variant in a SARS-CoV-2 infection-naive population

JJ Lau, SMS Cheng, K Leung, CK Lee, A Hachim… - Nature medicine, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant has demonstrated enhanced transmissibility and
escape of vaccine-derived immunity. Although first-generation vaccines remain effective …

Effectiveness of COVID-19 treatment with nirmatrelvir–ritonavir or molnupiravir among US veterans: target trial emulation studies with one-month and six-month …

KL Bajema, K Berry, E Streja, N Rajeevan… - Annals of internal …, 2023 - acpjournals.org
Background: Information about the effectiveness of oral antivirals in preventing short-and
long-term COVID-19–related outcomes in the setting of Omicron variant transmission and …

SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy: an observational study

GE Edelstein, J Boucau, R Uddin, C Marino… - Annals of Internal …, 2023 - acpjournals.org
Background: Data are conflicting regarding an association between treatment of acute
COVID-19 with nirmatrelvir− ritonavir (NR) and virologic rebound (VR). Objective: To …

Viral burden rebound in hospitalised patients with COVID-19 receiving oral antivirals in Hong Kong: a population-wide retrospective cohort study

CKH Wong, KTK Lau, ICH Au, EHY Lau… - The Lancet infectious …, 2023 - thelancet.com
Background Viral rebound after nirmatrelvir–ritonavir treatment has implications for the
clinical management and isolation of patients with COVID-19. We evaluated an unselected …

Treating Acute Covid-19—Final Chapters Still Unwritten

RT Gandhi, M Hirsch - New England Journal of Medicine, 2024 - Mass Medical Soc
Nirmatrelvir–ritonavir (Paxlovid [Pfizer]) is used as first-line therapy for nonhospitalized
persons with Covid-191 on the basis of the results of the Evaluation of Protease Inhibition for …

Effectiveness of Nirmatrelvir–Ritonavir Against the Development of Post–COVID-19 Conditions Among US Veterans: A Target Trial Emulation

GN Ioannou, K Berry, N Rajeevan, Y Li… - Annals of internal …, 2023 - acpjournals.org
Background: COVID-19 has been linked to the development of many post–COVID-19
conditions (PCCs) after acute infection. Limited information is available on the effectiveness …

Anti–SARS-CoV-2 pharmacotherapies among nonhospitalized US veterans, January 2022 to January 2023

L Yan, E Streja, Y Li, N Rajeevan, M Rowneki… - JAMA Network …, 2023 - jamanetwork.com
Importance Several pharmacotherapies have been authorized to treat nonhospitalized
persons with symptomatic COVID-19. Longitudinal information on the use of these therapies …

Drug treatment of COVID-19 infection

G Lui, G Guaraldi - Current opinion in pulmonary medicine, 2023 - journals.lww.com
Drug treatment of COVID-19 infection : Current Opinion in Pulmonary Medicine Drug treatment
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