Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma
incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we
found that ICBs induce cerebral edema in some patients and mice with glioblastoma …

Purpose: Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by
chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients …

Simple Summary Osteosarcoma is the most prevalent orthotopic bone tumor. Due to its high
metastatic properties, it has become the leading cause of cancer death worldwide. At this …

Monocytes are highly plastic innate immune cells that display significant heterogeneity
during homeostasis, inflammation, and tumorigenesis. Tumor-induced systemic and local …

Macrophages are ancient, phagocytic immune cells thought to have their origins 500 million
years ago in metazoan phylogeny. The understanding of macrophages has evolved to …

Allicin, an organic sulfur compound extracted from the bulb of Allium sativum, can potentially
prevent various tumors. Our previous study found that allicin can effectively suppress the …

Phototherapy-induced hypoxia in the tumor microenvironment (TME) is responsible for
diminished therapeutic efficacy. Designing an intelligent nanosystem capable of responding …

Cancer progression and metastasis due to tumor immune evasion and drug resistance is
strongly associated with immune suppressive cellular responses, particularly in the case of …