The term 'stress'–coined in 1936–has many definitions, but until now has lacked a
theoretical foundation. Here we present an information-theoretic approach–based on the …

Abstract Major Depressive Disorder (MDD) is one of the most common and debilitating
mental disorders; however, its etiology remains unclear. This paper aims to summarize the …

The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …

The recently uncovered key role of the peripheral and central nervous systems in controlling
tumorigenesis and metastasis has opened a new area of research to identify innovative …

The prefrontal cortex (PFC) is involved in working memory and self-regulatory and goal-
directed behaviors and displays remarkable structural and functional plasticity over the life …

Stress is a state of the mind, involving both brain and body as well as their interactions; it
differs among individuals and reflects not only major life events but also the conflicts and …

Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …

As the central organ of stress and adaptation to stressors, the brain plays a pivotal role in
behavioral and physiological responses that may lead to successful adaptation or to …

The brain is the key organ of stress reactivity, coping, and recovery processes. Within the
brain, a distributed neural circuitry determines what is threatening and thus stressful to the …

Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …